Liposoluble vitamins and naturally occurring carotenoids in porphyria cutanea tarda
Identifieur interne : 002B56 ( Main/Exploration ); précédent : 002B55; suivant : 002B57Liposoluble vitamins and naturally occurring carotenoids in porphyria cutanea tarda
Auteurs : E. Rocchi [Italie] ; A. M. Stella [Argentine] ; M. Cassanelli [Argentine] ; A. Borghi [Italie] ; N. Nardella [Italie] ; Y. Seium [Italie] ; G. Casalgrandi [Italie]Source :
- European Journal of Clinical Investigation [ 0014-2972 ] ; 1995-07.
English descriptors
- Teeft :
- Albumin levels, Antioxidant, Antioxidant system, Argentina, Blackwell science, Buenos aires, Carotenoid, Chronic liver disease, Cirrhosis, Cirrhotic, Cirrhotic patients, Cirrhotic population, Clin nutr, Clinical investigation, Cryptoxanthin, Cutanea, Different groups, European journal, Ferritin, Healthy controls, Immune response, Iron overload, Iron removal therapy, Liposoluble, Liposoluble vitamins, Liver cirrhosis, Liver damage, Liver iron overload, Lutein, Lycopene, Magnetic resonance imaging, Main laboratory findings, Nutritional status, Other carotenoids, Other hand, Overt liver cirrhosis, Oxidative, Oxidative damage, Plasma iron, Plasma levels, Plasma retinol, Porphyria, Porphyria cutanea tarda, Porphyrin, Previous studies, Retinol, Rocchi, Serum levels, Significant correlation, Significant decrease, Sporadic forms, Statistical significance, Tarda, Tocopherol, Tocopherol acetate, Unsaturated lipids, Urinary porphyrin levels, Virus infection, Vitamin, Vitamin factors.
Abstract
Abstract. The authors consider two groups of patients with overt sporadic porphyria cutanea tarda (PCT) from different continents, with the aim of evaluating the possible impairment of the liposoluble antioxida‐tive system, given the possible synergic effect of porphyrins and iron in promoting oxidative cellular damage. Twenty‐three Italian outpatients with overt sporadic PCT and 11 outpatients with PCT from Buenos Aires (Argentina) were matched with 60 patients with liver cirrhosis and 52 healthy Italian controls. Serum levels of alpha‐ and beta‐carotene, cryptoxanthin, zeaxanthin, lutein, lycopene, retinol and alpha‐tocopherol were detected by a high‐performance liquid chromatographic technique devised in our laboratory, which afforded an accurate and simultaneous resolution of all these compounds. The results point to a significant reduction in plasma levels of alpha‐ and beta‐carotene in both the PCT populations with respect not only to controls, but also to the cirrhotic population, which had more severe liver damage. Moreover, other carotenoids with proven antioxidative properties, like cryptoxanthin and lycopene, are greatly reduced in our PCT populations. This confirms the suggested synergic effect of iron and porphyrins in the oxidative intracellular damage with consequent depletion of antioxidative liposoluble molecules.
Url:
DOI: 10.1111/j.1365-2362.1995.tb01737.x
Affiliations:
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Cassanelli</name><affiliation wicri:level="1"><country xml:lang="fr">Argentine</country><wicri:regionArea>*Department of Biological Chemistry, University of Buenos Aires, Buenos Aires</wicri:regionArea><wicri:noRegion>Buenos Aires</wicri:noRegion></affiliation></author><author><name sortKey="Borghi, A" sort="Borghi, A" uniqKey="Borghi A" first="A." last="Borghi">A. Borghi</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>†Department of Internal Medicine, University of Modena, Modena</wicri:regionArea><wicri:noRegion>Modena</wicri:noRegion></affiliation></author><author><name sortKey="Nardella, N" sort="Nardella, N" uniqKey="Nardella N" first="N." last="Nardella">N. 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Casalgrandi</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>†Department of Internal Medicine, University of Modena, Modena</wicri:regionArea><wicri:noRegion>Modena</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">European Journal of Clinical Investigation</title><title level="j" type="alt">EUROPEAN JOURNAL OF CLINICAL INVESTIGATION</title><idno type="ISSN">0014-2972</idno><idno type="eISSN">1365-2362</idno><imprint><biblScope unit="vol">25</biblScope><biblScope unit="issue">7</biblScope><biblScope unit="page" from="510">510</biblScope><biblScope unit="page" to="514">514</biblScope><biblScope unit="page-count">5</biblScope><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="1995-07">1995-07</date></imprint><idno type="ISSN">0014-2972</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0014-2972</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Albumin levels</term><term>Antioxidant</term><term>Antioxidant system</term><term>Argentina</term><term>Blackwell science</term><term>Buenos aires</term><term>Carotenoid</term><term>Chronic liver disease</term><term>Cirrhosis</term><term>Cirrhotic</term><term>Cirrhotic patients</term><term>Cirrhotic population</term><term>Clin nutr</term><term>Clinical investigation</term><term>Cryptoxanthin</term><term>Cutanea</term><term>Different groups</term><term>European journal</term><term>Ferritin</term><term>Healthy controls</term><term>Immune response</term><term>Iron overload</term><term>Iron removal therapy</term><term>Liposoluble</term><term>Liposoluble vitamins</term><term>Liver cirrhosis</term><term>Liver damage</term><term>Liver iron overload</term><term>Lutein</term><term>Lycopene</term><term>Magnetic resonance imaging</term><term>Main laboratory findings</term><term>Nutritional status</term><term>Other carotenoids</term><term>Other hand</term><term>Overt liver cirrhosis</term><term>Oxidative</term><term>Oxidative damage</term><term>Plasma iron</term><term>Plasma levels</term><term>Plasma retinol</term><term>Porphyria</term><term>Porphyria cutanea tarda</term><term>Porphyrin</term><term>Previous studies</term><term>Retinol</term><term>Rocchi</term><term>Serum levels</term><term>Significant correlation</term><term>Significant decrease</term><term>Sporadic forms</term><term>Statistical significance</term><term>Tarda</term><term>Tocopherol</term><term>Tocopherol acetate</term><term>Unsaturated lipids</term><term>Urinary porphyrin levels</term><term>Virus infection</term><term>Vitamin</term><term>Vitamin factors</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract. The authors consider two groups of patients with overt sporadic porphyria cutanea tarda (PCT) from different continents, with the aim of evaluating the possible impairment of the liposoluble antioxida‐tive system, given the possible synergic effect of porphyrins and iron in promoting oxidative cellular damage. Twenty‐three Italian outpatients with overt sporadic PCT and 11 outpatients with PCT from Buenos Aires (Argentina) were matched with 60 patients with liver cirrhosis and 52 healthy Italian controls. Serum levels of alpha‐ and beta‐carotene, cryptoxanthin, zeaxanthin, lutein, lycopene, retinol and alpha‐tocopherol were detected by a high‐performance liquid chromatographic technique devised in our laboratory, which afforded an accurate and simultaneous resolution of all these compounds. The results point to a significant reduction in plasma levels of alpha‐ and beta‐carotene in both the PCT populations with respect not only to controls, but also to the cirrhotic population, which had more severe liver damage. Moreover, other carotenoids with proven antioxidative properties, like cryptoxanthin and lycopene, are greatly reduced in our PCT populations. This confirms the suggested synergic effect of iron and porphyrins in the oxidative intracellular damage with consequent depletion of antioxidative liposoluble molecules.</div></front></TEI><affiliations><list><country><li>Argentine</li><li>Italie</li></country></list><tree><country name="Italie"><noRegion><name sortKey="Rocchi, E" sort="Rocchi, E" uniqKey="Rocchi E" first="E." last="Rocchi">E. Rocchi</name></noRegion><name sortKey="Borghi, A" sort="Borghi, A" uniqKey="Borghi A" first="A." last="Borghi">A. Borghi</name><name sortKey="Casalgrandi, G" sort="Casalgrandi, G" uniqKey="Casalgrandi G" first="G." last="Casalgrandi">G. Casalgrandi</name><name sortKey="Nardella, N" sort="Nardella, N" uniqKey="Nardella N" first="N." last="Nardella">N. Nardella</name><name sortKey="Rocchi, E" sort="Rocchi, E" uniqKey="Rocchi E" first="E." last="Rocchi">E. Rocchi</name><name sortKey="Seium, Y" sort="Seium, Y" uniqKey="Seium Y" first="Y." last="Seium">Y. Seium</name></country><country name="Argentine"><noRegion><name sortKey="Stella, A M" sort="Stella, A M" uniqKey="Stella A" first="A. M." last="Stella">A. M. Stella</name></noRegion><name sortKey="Cassanelli, M" sort="Cassanelli, M" uniqKey="Cassanelli M" first="M." last="Cassanelli">M. Cassanelli</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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